Saginomiya Isumi is a purple-haired girl who always wears a kimono and, sometimes, a stole. She is Nagi's best friend; they met at a party a long time ago. When all the other children, Sakuya included, laughed at Nagi's first attempt at writing her own manga, Isumi took interest in it and asked Nagi how it ends. Nagi then asked Isumi (in a childish sense) to marry her. Like Nagi, Isumi is very rich; however, Isumi is soft-spoken, kind, and a good cook. While she does not have an awful sense of direction, she constantly gets lost due to the fact that she is apt to forget her destination and believes herself to be reliable and independent (a belief further enforced by the flighty nature of her mother and grandmother); the fact that she can disappear from people's eyes instantaneously only complicates the matter. She also has a habit of saying, when she doesn't understand how to use a machine such as a cellular phone or a vending machine, that the machine is broken. She displays a high level of empathy for Nagi's feelings, yet she does not recognize Wataru's love for her, a fact that Nagi, Maria, and Hayate comment on.
In volume five of the manga, it is revealed she can perform exorcisms. Humorously, she calls this power "hand soap", though Hayate assumes she means "hand power". She loves Hayate and does not wish to see him sad, although in the manga she loses some of these feelings after her favorite TV character was back on air.
Isumi is the inheritor of the secret mystical power called Jutsushiki Hachiyo, the spell of the eight leaves. This power is only inherited by a chosen female child in the Saginomiya family. In volume 11, she loses this power, which causes some slight distress to Hayate as he would have to literally bleed through grueling trouble in order for her to regain it, but she rejects his help, saying that she does not wish to cause other people harm for her own ends. However, in volume 12, when Hayate is on the verge of tears thinking of a way to save Nagi from being blasted off into outer space, she kisses Hayate on the cheek (while he is bleeding profusely after being struck on the head by Isumi's great-grandmother) and regains her power, sending Hayate speeding towards the UFO to save Nagi.
Later in the story, Isumi does rather a prominent role regarding the events about Athena and Hayate's past, by aiding Hayate in several ways during the fight against King Midas. It is also revealed that her hair temporarily pales whenever she overuses her power.
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Dono yō ni watashi wa on'nanoko ni naru no desu ka?
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